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KMID : 1200020130370040286
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Diabetes & Metabolism Journal
2013 Volume.37 No. 4 p.286 ~ p.290
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Effect of Granulocyte Colony-Stimulating Factor on the Peripheral Nerves in Streptozotocin-Induced Diabetic Rat
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Lee Kyung-Ae
Park Kyung-Taek
Yu Hea-Min
Jin Heung-Yong
Baek Hong-Sun
Park Tae-Sun
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Abstract
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There are controversial reports about the effect of granulocyte colony-stimulating factor (G-CSF) in peripheral nerve protection. Therefore, the present study aimed to investigate the effect of G-CSF on peripheral nerves in streptozotocin (STZ) induced diabetic rats. After STZ or vehicle injection, rats were divided into five groups (n=6) as follows: normal+vehicle, normal+G-CSF (50 μg/kg for 5 days), diabetes mellitus (DM)+vehicle, DM+G-CSF (50 μg/kg for 5 days), and DM+G-CSF extension (50 μg/kg for 5 days and followed by two injections per week up to 24 weeks). Our results showed that the current perception threshold was not significantly different among experimental groups. G-CSF treatment inhibited the loss of cutaneous nerves and gastric mucosal small nerve fibers in morphometric comparison, but statistical significance was not observed. The present results demonstrated that G-CSF has no harmful but minimal beneficial effects with respect to peripheral nerve preservation in diabetic rats.
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KEYWORD
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Diabetes mellitus, Granulocyte colony-stimulating factor, Peripheral nerves
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